Mosquito gut microbiota mediate malaria transmission?

Transmission success of malaria parasites varies between night and day, aligned to daily rhythms in the behavior and physiology of Anopheline mosquito vectors. 

Midgut microbial consortia within mosquitoes facilitate or block malaria parasite development via modulation of vector immune responses, nutrient metabolism, the midgut environment, and microbial products.

Midgut microbial abundance and composition oscillates with a daily rhythm due to bidirectional feedback between rhythms of mosquitoes and microbes, potentially driving time-of-day dependencies in malaria transmission.

Examining how rhythms associated with mosquito gut microbial communities may mediate malaria transmission is urgently needed, given that shifts in the time of day at which biting occurs underpin residual transmission.

Disrupting rhythmic microbe–malaria– mosquito interactions offers innovative approaches to prevent transmission.

https://www.cell.com/trends/parasitology/fulltext/S1471-4922(25)00231-4

https://sciencemission.com/microbes-mediate-rhythmic-malaria