Chronic inflammation in colorectal cancer

The rise in early-onset colorectal cancer cases and related deaths emphasizes the urgent need for focused research and targeted clinical interventions to improve treatment outcomes. 

Several early-life exposomal factors and the resulting systemic chronic lowgrade inflammation could explain the risk of developing early-onset colorectal cancer.

Chronic low-grade inflammation, resulting from exposure to environmental pollutants/toxins, lifestyle factors/ diseases, and microbiome dysbiosis, is a key trigger for early-onset colorectal cancer tumorigenesis and progression.

Chronic low-grade inflammation-specific biomarkers could enable early-onset colorectal cancer prediction, early detection, recurrence prediction, and offer targets for prevention and therapy.

Combining anti-inflammatory diets, drugs, and personalized chronic lowgrade inflammation-targeted approaches to reduce inflammation may support early-onset colorectal cancer prevention and improve therapeutic outcomes.

https://www.cell.com/trends/cancer/fulltext/S2405-8033(26)00108-1

https://sciencemission.com/Defying-inflammation-driven-early-onset-CRC