Inflammatory gene transcription regulation
While we recognize that inflammatory responses are essential for immunity to microbial infections, it is evident from clinical proof that these responses must be properly controlled to prevent potential detrimental consequences.
Over the past decades, multiple immunosuppressive mechanisms have been identified at distinct levels, including mechanisms that target immune receptor complexes and regulate signal transduction.
However, the molecular mechanisms by which inflammatory gene transcription is precisely finetuned remain poorly defined.
Here, the author highlight that a comprehensive understanding of how the ubiquitination–deubiquitination process directly controls the transcription of inflammatory genes may reveal novel avenues for therapeutic intervention.
Finally, the review provides insight into the importance of understanding the spatiotemporal regulation of inflammatory gene transcription at the gene specific level.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(26)00008-3
