Cross talk between microbe derived tryptophan metabolites and neuroimmune system
Tryptophan metabolites derived from the host–microbe co-metabolism system are sensed by the neural and immune systems to regulate tissue homeostasis and organ crosstalk.
Bidirectional crosstalk exists between tryptophan metabolism and the neuroimmune network.
Neuroimmune regulation by tryptophan metabolites enriches a neuro-immuno-metabolic perspective on the biologic underpinnings of host– microbe interactions.
Neuroimmune sensing of tryptophan metabolites may provide alternative targets for microbiome-based therapeutics.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00260-6
