E.Coli mediated GABA metabolism imbalance linked to autism
Although autism spectrum disorder (ASD) has been linked to alterations in gut microbiota (GM), the specific functional architecture remains elusive.
The researchers find an elevated gut microbial GABA/glutamate ratio in 203 children with ASD independent of age and gender, establishing it as a marker associated with ASD diagnosis.
They elucidate that abnormal GABA metabolism is linked to the overrepresentation of Escherichia in the gut.
These findings provide insights into strategies aiming at restoring neurotransmitter homeostasis in ASD.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00690-6
