Engineered cytokine IL-10 enhances neurogenesis and improves cognition in old age
The brain function declines with age and immune cells play a key role in old age related brain dysfunction.
Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear.
The authors show that the old brain contains exhausted T cells and unbalanced microglial inflammation. They also demonstrate that checkpoint inhibition in old brains activates T cells and microglial inflammation.
The researchers show that targeting immune cells with an engineered IL-10 variant rebalances inflammatory programs in microglia, improves neurogenesis, and enhances cognition in old mice.
https://www.cell.com/immunity/fulltext/S1074-7613(26)00038-5
