Ferroptosis regulation in lysosome

Lysosomal iron and cathepsin B contribute to ferroptotic cell death. 

Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation.

Beyond its classic role as a cystine/ glutamate antiporter, solute carrier family 7 member 11 also counteracts lysosomal acidification, thereby reducing ferroptosis sensitivity.

Selective autophagy modulates ferroptosis by controlling the degradation of ferritin, lipid droplets, mitochondria, and key regulatory proteins.

Targeting lysosomal membrane permeabilization, lysosomal iron, lysosomal pH, or selective autophagy provides promising avenues for therapeutic intervention in ferroptosis.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(26)00038-3

https://sciencemission.com/Lysosome-hub-for-ferroptosis-regulation