Ferroptosis trigger in neurodegenerative diseases
Ferroptosis is emerging as a central player in neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
The induction and propagation of ferroptosis stem from the failure of lipid peroxidation defense systems.
Validated biomarkers of ferroptosis in neurodegenerative diseases are currently lacking. However, ferroptosis can be inferred based on accumulation of iron, excessive lipid peroxidation, and reduced glutathione levels.
Although pathophysiologically relevant triggers of ferroptosis remain elusive, emerging evidence suggests that ferroptosis is orchestrated by a context dependent and synergistic interactions between the pathological hallmarks of neurodegenerative diseases, including neuroinflammation, protein aggregation, mitochondrial dysfunction, altered lipid metabolism, and iron accumulation.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00138-9
