Frog-derived synthetic peptides against Gram-negative pathogens
The authors discuss the peptides from frogs are promising antibiotic candidates.
Frog-derived synthetic peptides selectively targeted Gram-negative pathogens, sparing beneficial microbiota and human cells.
Structure-guided modifications improved the antimicrobial potency by optimizing hydrophobicity and net charge.
Lead peptides effectively reduced bacterial loads in murine models of Pseudomonas aeruginosa and Acinetobacter baumannii infections without toxicity.
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(25)00044-7
