Gut microbial metabolism in ferroptosis and colorectal cancer
Ferroptosis in colorectal cancer (CRC) cells could be regulated by both intrinsic and extrinsic pathways.
Gut microbes act as an external factor to modulate ferroptosis susceptibility of CRC cells.
Multiple metabolites derived from gut microbes, such as vitamins, bile acid, short-chain fatty acids, and tryptophan metabolites, influence the ferroptosis sensitivity of CRC cells.
There is a tight correlation between gut microbial metabolism-mediated ferroptosis and CRC, which provides a novel therapeutic approach for CRC.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00163-6
https://sciencemission.com/Gut-microbial-metabolism-in-ferroptosis-and-CRC
