cGAS–STING signaling is organelle-specific!
Organelle-restricted signaling circuits remodel cGAS–STING functions, extending its reach beyond canonical type I interferon induction.
Subcellular trafficking of STING determines its activation and termination dynamics.
cGAS–STING acts as a central hub linking innate immune sensing to translational control, metabolic rewiring, organelle homeostasis, and cell-fate determination, influencing a spectrum of diseases.
An organelle-centric perspective exposes context-specific vulnerabilities in cGAS–STING, paving the way for more precise and selective immunotherapies.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00198-9
