Gut microbiota–prostate cancer crosstalk

Recent studies emphasize the crucial influence of gut microbiota dysbiosis on prostate cancer (PCa) development and progression. 

Specific bacteria and derived functions impact treatment outcomes. Western dietary habits are identified as significant risk factors for PCa, possibly by altering gut microbiota composition and function.

Key gut-derived metabolites, such as the short-chain fatty acid butyrate and microbial-derived androgens, are linked to PCa aggressiveness and tumor growth.

Long-chain omega-3 polyunsaturated fatty acids modulate gut microbiota, reduce PCa tumor growth in mouse models, and are associated with tumor downgrade at radical prostatectomy in patients with PCa.

The gut–PCa axis presents promising opportunities for novel diagnostic biomarkers and therapeutic strategies for PCa management.

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00087-5

https://sciencemission.com/gut-microbiota%E2%80%93prostate-cancer