Adult hippocampal neurogenesis
Formation of new neurons is a process called neurogenesis, was previously believed to occur only during embryonic stages in the mammalian central nervous system but the evidence in the last few decades suggest the presence of adult neurogenesis that may contribute to the physiological function as well as a range of neurological or psychiatric disorders.
The authors in this review discuss adult hippocampal neurogenesis including proliferation, differentiation, maturation, and synapse formation of neural stem cells. They also discuss how new born adult neurons play a role in learning and memory behaviors and their role in various diseases.
They also discuss mechanisms regulating adult hippocampal neurogenesis and possible therapeutic strategies and targets that can be leveraged for future clinical translations.
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(25)00204-8
