Roles of H3K4 methylation in biology and disease
The protein complexes catalyzing the mono-, di-, and trimethylation and demethylation of H3 lysine 4 (H3K4), as well as those that read these modifications, are essential for differentiation and development.
More specifically, trimethylated H3K4 (H3K4me3) plays critical roles in regulating gene expression, as well as transcriptional memory and consistency.
Recent studies have indicated that the roles of H3K4me3 in gene expression may be different from what was originally thought.
Somatic alterations in genes regulating the methylation and demethylation of H3K4 are common in cancer.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00115-6
