Insulin signaling and metabolism modulator!
Biliverdin reductase-A (BVRA) acts as a redox-sensitive regulator of insulin signaling across multiple tissues.
BVRA decline precedes canonical markers of insulin resistance and represents a newly discovered and early marker of insulin resistance in both the periphery and the brain.
BVRA modulates key nodes, such as IRS1, Akt, GSK3β, AMPK, and mTOR, preserving metabolic balance.
Loss or dysfunction of BVRA promotes oxidative stress, mitochondrial failure, and neurodegeneration.
BVRA-targeted peptides restore insulin sensitivity and mitochondrial function in animal models of disease.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(25)00176-6
