Mechanism of heart failure in chronic kidney disease

Heart failure (HF) is highly prevalent among patients with chronic kidney disease (CKD), yet the exact mechanisms remain unclear. 

The researchers demonstrate that E. coli-derived indoxyl sulfate (IS) promotes heart failure progression in CKD via AHR-CYP1B1 signaling.

The authors show that administering  probiotics reduced E. coli abundance and IS levels thereby improving cardiac outcomes in rats and CKD patients. 

Thus, targeting the microbiota-indoxyl sulfate pathway offers diagnostic and therapeutic potential for CKD-related HF.

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00340-3

https://sciencemission.com/Gut-microbiota-derived-indole-sulfate-promotes-HF-in-CKD