Beta cells intrinsic sensor regulates secretory activity

How pancreatic β cells regulate excessive insulin release is not clearly understood.

The researchers show that mTORC1 in β cells acts as an activity sensor, activated by the same signals that trigger insulin secretion.

This activation, in turn, inhibits insulin release via RhoA-dependent actin remodeling, establishing a negative feedback loop that allows β cells to intrinsically regulate their own activity.

inhibition of mTORC1 during glucose stimulation enhances insulin release, further confirming the role of mTORC1 in regulating insulin secretion.

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00418-8

https://sciencemission.com/Beta-cells-intrinsically-sense-and-limit-their-secretory-activity