Health-span extension using energy restriction and exercise
Human clinical trials show that dietary restriction (DR), combined with a nutrient rich pescatarian diet and structured physical activity, effectively reduces the risk of age-related metabolic diseases by targeting key biological pathways, including nutrient sensing, insulin sensitivity, inflammation, and mitochondrial function.
Emerging evidence highlights the potential of glucagon-like peptide 1 (GLP-1) receptor agonists to mimic some of the metabolic benefits of DR, thereby offering a promising pharmacological intervention for chronic disease prevention and metabolic health improvement – but only if supported by a high-quality diet and regular exercise to preserve muscle and bone mass.
Integrating lifestyle interventions with targeted pharmacological therapies can shift healthcare from reactive treatment to proactive prevention, thus promoting healthy longevity, reducing chronic disease burden, and lowering healthcare costs while enhancing societal wellbeing and productivity.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(25)00076-1
