Integrator in development and disease
Integrator, a multiprotein complex associated with RNA polymerase II (RNAPII), crucially regulates transcription.
It directly interacts with the RPB1 C-terminal domain (CTD) that enables precise RNA cleavage and termination.
It plays an essential role in transcription initiation, release of paused RNAPII, and transcription elongation.
Integrator has a critical involvement in generating enhancer-derived RNAs and managing DNA damage responses.
Dysregulation or mutations of integrator linked to neurodevelopmental disorders and various cancers.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00212-6
