MAFLD is a ferroptotic disease
The identification of hyperoxidized PRDX3 as a specific marker for ferroptosis, a cell death pathway driven by phospholipid peroxidation, allows tshe detection of ferroptotic cells in physiological settings.
Applying this marker, ferroptosis was found to be responsible for hepatic injury caused by metabolic dysfunction associated fatty liver disease (MAFLD).
The recognition that MAFLD is driven by ferroptosis provides novel insights into the pathogenesis of the disease, stimulating investigations into understanding how dietary and genetic risk factors modulate the progression of MAFLD through regulating the sensitivity of hepatocytes to ferroptosis.
This recognition may lead to novel strategies to combat MAFLD by inhibiting ferroptosis.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00194-7
