Mitochondria-derived vesicles in aging and neurodegeneration
Neuronal energy metabolism is controlled by the mitochondria and mitochondrial quality control (MQC) system regulates various processes like proteostasis, dynamics, biogenesis, and mitophagy.
Mitochondria derived vesicles (MDVs) are small vesicles that bud from mitochondria and selectively transport damaged mitochondrial proteins, lipids, and nucleic acids to endolysosomal compartments or other intracellular destinations, enabling rapid and localized responses to mitochondrial stress and may help to avoid or delay irreversible mitochondrial damage.
The researchers in this review summarize MQC mechanisms in neurons, with a focus on MDVs, their dysregulation during aging and neurodegeneration, and implications for biomarkers and therapeutic strategies.
https://www.sciencedirect.com/science/article/pii/S0047637426000199
