MYCN-driven metabolic microenvironment of neuroblastoma

Understanding how the MYCN oncogene reshapes both intra-tumoral and microenvironmental metabolic circuits should be considered in the design of novel metabolic therapeutic approaches for high-risk neuroblastoma (NB). 

Targeting key MYCN-driven metabolic circuits may reprogram the tumor microenvironment (TME) of high-risk NB and improve immunotherapy approaches.

Identifying essential metabolic nodes of effector immune cells will inform metabolic-based strategies to optimize antitumor activity.

Systemic nutrition and circadian homeostasis crucially impact tumor metabolism and progression, and could be leveraged to develop novel therapeutic approaches for MYCN-driven cancers.

Rapid developments in methods to characterize the metabolic landscape at a single-cell resolution will enable more rationally designed metabolic therapies.

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00193-5

https://sciencemission.com/MYCN-driven-metabolic-microenvironment-of-neuroblastoma