Tertiary lymphoid structures in the central nervous system

Tertiary lymphoid structures (TLSs) have been identified in many central nervous system (CNS) diseases, including multiple sclerosis (MS), glioma, infectious diseases, spinal cord disorders, and ischemic stroke. A more advanced stage of MS has been associated with certain TLSs. 

However, tumor-associated TLSs have been shown to correlate with a greater treatment response rate and a better prognosis in mouse models of glioblastoma.

TLSs may serve as ectopic germinal centers, which contribute to antibody diversification, B cell development, isotype switching, and oligoclonal growth.

Dynamic and manipulable processes of TLSs provide new opportunities for modulating the priming of brain reactive T cells.

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(24)00281-8

https://sciencemission.com/Tertiary-lymphoid-structures-in-the-central-nervous-system