Mast cells as signal converters between tissues and neurons
Mast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors.
They sense antigen and possibly toxins driving avoidance behavior, which can prevent inflammation and tissue damage.
Beyond classical immunity, mast cells rapidly activate antigen expulsion responses and initiate nociception. These reflexes promote host-protective behavior and maintain tissue integrity.
https://www.cell.com/immunity/fulltext/S1074-7613(24)00531-4
