Brain aging and rejuvenation at single-cell resolution
It is not clear how changes within individual brain cells result in age-related cognitive dysfunction and susceptibility to neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases.
New single-cell technologies, such as single-cell transcriptomics have helped to characterize brain aging at single-cell resolution.
In this review, the researchers discuss single-cell omics studies at the cell type specific and cell-cell interactions level in brain aging.
They highlight different rejuvenation interventions using single-cell omics studies and propose new directions, including models of brain aging and neural stem cells as a focal point for rejuvenation.
