Measles virus polymerase complex structure unraveled!

There is no approved antivirals currents available for the measles virus (MeV).

The researchers determined the cryo-electron microscopy structures of the MeV polymerase complex alone and bound to two non-nucleoside inhibitors, ERDRP-0519 and AS-136A.

The authors uncover an allosteric inhibitory mechanism and reveal a dual-inhibitory effect of the inhibitor on the Nipah virus polymerase.

They show that Inhibitor binding induces a conformational change in the catalytic loop, allosterically locking the polymerase in an inactive “GDN-out” state.

https://www.cell.com/cell/fulltext/S0092-8674(25)00683-X

https://sciencemission.com/Structures-of-the-measles-virus-polymerase-complex