Mechanism to break Salmonella colonization resistance
The authors show that initial rise in the abundance of the pathogen in the feces coincided with a reduction in the cecal concentrations of acetate and butyrate and an increase in epithelial oxygenation.
The researchers show that Salmonella overcomes colonization resistance when the microbiota is compositionally intact by disrupting epithelial hypoxia.
Pathogen outgrowth is fueled by catabolizing simple sugars, such as glucose, using a combination of aerobic respiration and mixed acid fermentation.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00284-1
