Merlin–YAP signaling
Solid-like biomolecular condensates formed by Merlin at the plasma membrane have a pivotal role in activating the Hippo pathway in epithelial tissues.
The formation of Merlin condensates is further regulated by phosphoinositides and cytoskeletal tension.
The regulation of the Hippo pathway core kinase cascade is complex and involves diverse, redundant regulators that complement each other's functions in many conditions.
Contrary to its canonical role in promoting cell proliferation and inhibiting cell death, yes-associated protein (YAP)/ transcriptional coactivator with PDZ binding motif (TAZ) activation also promotes ferroptotic cell death.
Recent studies identify synthetic lethal targets, such as focal adhesion kinase (FAK), glucose-6-phosphate dehydrogenase (G6PD), and acyl-CoA synthetase long-chain family member 3 (ACSL3), offering new therapeutic strategies for NF2-deficient tumors.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00205-3
