Improving Mitochondrial Function in Neurodegenerative Diseases
Mitochondria regulate bioenergetics, redox balance, and neuronal survival and mitochondrial dysfunction has been linked to various diseases including aging and neurodegeneration.
The researchers in this review discuss the mechanisms of mitochondrial function and failure linked to Alzheimer’s and Parkinson’s disease, and evaluate the role of phytochemicals and mitochondria-targeted small molecules as therapeutic agents.
The authors also discuss the role next gen technologies like nanoparticles for mitochondrial delivery, mtDNA editing, and mitochondrial transfer.
The authors believe that mitochondria-directed therapies may serve as useful tools to treat neurodegenerative disorders.
https://www.sciencedirect.com/science/article/pii/S1043661826001428
