Mitochondrial respiratory complexes in aging

Mitochondrial dysfunction is a key hallmark of aging, with a core feature embracing the defects in the oxidative phosphorylation (OXPHOS) system. 

The origins and consequences of age associated OXPHOS alteration are the focus of research. The lifecycle of the OXPHOS system could be vulnerable to aging, with some traits (such as mtDNA mutations) playing a primary role.

Adjustments in OXPHOS functionality form part of the response to age-associated pathologies.

OXPHOS fate is heterogeneous across aged organs and cell types. ‘

New methodological advances will accelerate development in the field and help to address outstanding questions.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00042-X

https://sciencemission.com/mitochondrial-respiratory-complexes-in-aging