Neurodevelopmental disorders from Polycomb complex missense mutations
The causes of many neurodevelopmental disorders (NDDs) is yet to be determined.
The researchers report new missense mutations in the Polycomb repressive complex 1 (PRC1) E3 ligases RNF2 and RING1 in individuals with neurodevelopmental disorders.
Functional dissection of a deleterious variant reveals that balanced co-recruitment of Polycomb complexes to chromatin is essential for proper neurogenesis and for normal brain function and behavior.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00065-1
