Probiotic intervention strategies
Defining a 'healthy microbiome' is complex and context-dependent, varying across individuals, body sites, and environmental conditions.
Currently, there is a lack of data on the human microbiome across certain geographic regions, age groups, and anatomical sampling sites.
These knowledge gaps hamper the development of globally effective microbiome-based treatments.
Personalized or regionally adapted probiotics may be more effective, especially when based on local strains and microbiome compositions. Personalization should be assessed based on a taxon’s adaptability, that is, the capacity to either genomically or phenotypically change to be able to colonize a given host/niche.
Personalized and local probiotics may not be cost-effective in market-driven systems. Broader, holistic health strategies, including traditional knowledge and ecosystem preservation, may be more sustainable and equitable.
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(25)00336-1
