Progesterone’s immunoregulatory role  during embryo implantation and pregnancy

Progesterone modulates innate and adaptive immune responses, establishing the immune tolerance required for successful implantation and pregnancy maintenance. 

Altered progesterone levels or signaling impairs immune homeostasis and increases the risk of implantation failure, miscarriage, and pregnancy complications.

Clinical studies evaluating progesterone or progestin administration have reported heterogeneous outcomes in preventing miscarriage and other pregnancy-related complications.

Increased progesterone levels during pregnancy may contribute to the modulation of immune responses, potentially affecting disease activity and postpartum relapse in autoimmune conditions.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(26)00044-5

https://sciencemission.com/immunoregulatory-role-of-progesterone