Protein biogenesis requires ribosome-NAC collaboration
Cotranslational factors support the ribosomes during protein synthesis by choreographing by diverse functions like folding, sorting etc for different set of proteins targeting different organelles.
At the ribosomal exit tunnel recent studies have identified nascent polypeptide-associated complex (NAC) as a central coordinator of this process by sensing nascent signals and dynamically modulating factor access to the ribosome.
Thus, NAC act as a molecular hub that organizes cotranslational interactions into efficient and orderly protein biogenesis pathways.
Researchers in this review discuss the mechanistic role of NAC in maintaining fidelity in protein biogenesis.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)01030-5
