Protein identification and sequencing using nanopore technology

Thanks to recent developments, nanopore tools that fingerprint proteins or peptides are within reach, while methods for nanopore protein sequencing still require further development. 

A variety of strategies are currently under development, such as sensing full-length or fragmented proteins and controlling the motion of protein analytes through the nanopore.

Future improvements may leverage cutting-edge approaches, including electroosmotic flux (EOF) optimization, pore functionalization, and analyte modifications, to enhance nanopore performance and broaden its applicability.

https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00109-4

https://sciencemission.com/nanopore-technology-for-protein-identification-and-sequencing