Role of Ripk2 in aging mice following stroke
Although receptor-interacting serine/threonine kinase 2 (RIPK2) is an important mediator in the post-stroke inflammatory signaling cascade in young animals, its role in aged mice post-stroke is unclear.
The researchers in this study knocked out RIPK2 in aged mice and evaluated its role in post-stroke inflammation.
They show that global deletion of Ripk2 (Ripk2-/-) in aged mice resulted in smaller infarct volume and improved performance on cognitive tests compared to aged wildtype (WT) mice.
Also, aged Ripk2-/- mice had less gliosis in the ipsilateral cortex than the aged WT control mice.
https://www.sciencedirect.com/science/article/pii/S2589958925000015
