MicroRNA’s in neurodegenerative diseases
Currently, there is no cure for various neurodegenerative diseases (NDs) like Alzheimer's and Parkinsons. Various biochemical and morphological changes takes place in the brain before severe clinical symptoms become apparent. Therefore, early diagnosis might have therapeutic advantage.
Various diagnostic markers have been identified so far and microRNA’s are one among them.
This review discusses how miRNAs and RNA-binding proteins are implicated in the pathogenesis of NDs.
They also describe the role of miRNAs in post-translational modifications (PTMs), ubiquitination or de-ubiquitination processes and regulating protein function and stability.
The review discusses the significance of miRNAs as biomarkers for early disease detection.
https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1386735/full
