Neuronal activity-regulated miRNAs shape synapses
MicroRNAs (miRNAs) are emerging as crucial regulators that bridge neuronal activity with the molecular changes underlying synaptic plasticity.
Neuronal activity modulates the function of miRNAs across their entire life cycle, influencing transcription, transport, local maturation, and decay.
Transcriptional control of miRNAs contributes to neuron-wide structural adaptations, while synapse-specific regulation allows for rapid, localized control of protein synthesis.
Activity-regulated miRNAs provide an essential layer of control, coordinating the complex gene expression programs required for shaping synapses during learning and memory.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00121-3
