cGAS-STING signaling in neuroinflammation

The authors sin this review discuss the molecular mechanisms underlying the canonical innate immune responses that are triggered by cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway leading to the production of type I IFNs and pro-inflammatory cytokines. 

They also discuss noncanonical roles of cGAS in chromatin organization and RNA metabolism.

cGAS-STING signaling also plays key roles in brain function, including glial state regulation, neuronal homeostasis, blood-brain barrier integrity, and peripheral immune surveillance, and neuroinflammation and neuropathology in neurodegenerative diseases.

The researchers also discuss the role of cGAS and STING inhibitors in treating the brain disorders.

https://www.jci.org/articles/view/204550

https://sciencemission.com/cGAS-STING-signaling-in-neuroinflammation