mRNA’s transcription to cytoplasmic export!
The passage of mRNAs through nuclear processing and export to the cytoplasm is mediated by a spectrum of RNA binding proteins and detailed information about their structure and the way in which they interact with mRNAs to generate messenger ribonucleoprotein complexes (mRNPs) is emerging.
Mature mRNPs, in which processing has been completed, are compacted by the transcription-export (TREX) complex and Ser/Arg-rich proteins, after which they are remodeled to facilitate export through nuclear pores to the cytoplasm for translation.
DEAD-box ATPases mediate much of the extensive remodelling of mRNPs in this pathway that is necessary both to generate export-competent mRNPs that contain nuclear export factors and to remove these factors in the cytoplasm to prevent the mRNA returning to the nucleus.
The TREX2 complex and Tho1/SARNP orchestrate key features of the remodelling required to produce an export competent mRNP.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00134-3
