Leveraging cancer metabolism via ferroptosis

Ferroptosis is a cell death process at the intersection of distinct metabolic pathways, ranging from labile iron and oxidizable lipid production to protective antioxidant mechanisms. 

Adaptations in cancer metabolism promote cell proliferation while shaping ferroptosis sensitivity.

Different oncogenic signaling pathways have distinct interconnections with ferroptosis-promoting or ferroptosis inhibiting metabolism.

The ‘ferroptosis-inducing + ferroptosis priming’ paradigm can leverage tumor specific metabolic pathways, ensuring that ferroptosis becomes a more targeted and efficient tumor-killing strategy.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(26)00039-5

https://sciencemission.com/Ferroptosis-and-cancer-metabolism