Mechanism of cellular debris clearance and myelin renewal

Myelin debris clearance during demyelination is orchestrated by a demyelination associated microglia (DMAM) and is regulated by peroxisomal metabolism. 

The researchers evaluated the role of peroxisome integrity in DMAM in microglia along with conditional knockout of peroxisome biogenesis factor 5 (PEX5).

The authors demonstrate impaired lipid catabolism in PEX5cKO DMAMs and intralysosomal crystals.

Aberrant lipid processing was accompanied by elevated lysosomal damage markers and downregulation of the lipid exporter gene Apoe, consistent with defective lipid clearance.

Furthermore, the disruptions in PEX5cKO DMAMs were associated with defective myelin debris clearance and impaired remyelination. 

https://www.jci.org/articles/view/179985

https://sciencemission.com/Peroxisomal-integrity-in-demyelination