Extracellular ATP is an environmental cue in bacteria
Extracellular ATP (eATP) acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. But, how intestinal bacteria responds to elevated eATP is not clear.
The researchers show that extracellular ATP reprograms the transcriptional and metabolic landscapes of gut bacteria, impacting biofilm formation, production of bioactive metabolites, bacterial envelope composition,
The authors show that eATP altered the sensitivity to antibiotics and antimicrobial peptides and also controlled virulence factor expression.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01127-1
