3D chromatin organization in aging
Aging and senescence alter 3D chromatin organization, including compartments, topologically associating domains (TADs), and enhancer–promoter interactions, leading to altered gene expression.
Chromatin changes in senescent and physiological aging exhibit distinct patterns, such as compartmentalization and TAD boundary alterations.
Aging-associated chromatin reorganization and aging trajectories vary between cell types.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00178-3
