How stress-enhances fear memory?
The researchers previously shown that predator odor stress elevates GluA2 transcription in cerebellar molecular layer interneurons (MLIs)
The researchers in this study reveal that adenylyl cyclase 5 (AC5) in cerebellar interneurons drives a stress and norepinephrine-induced increase in synaptic GluA2 expression via a PKACREB pathway.
Deletion of AC5 abolishes the enhancement of fear memory after stress.
This highlights the importance of AC5 in both interneuron plasticity and fear memory potentiation.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01531-6
