Pharmacological enhancement of fear extinction
Treatments for anxiety and trauma related disorders rely partly on extinction learning.
Specific pharmacological agents are proposed to enhance extinction learning processes, but human studies yield mixed results.
The authors review whether the methodologies of human fear conditioning and treatment studies involving d-cycloserine (DCS), glucocorticoids, and L-DOPA are consistent with extinction learning principles.
Many existing studies are not optimally designed to detect extinction effects.
https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(25)00157-3
