Senescence–autophagy axis in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis is an aging related lung disease with a poor prognosis and limited treatments. 

Senescence and impaired autophagy are key hallmarks of idiopathic pulmonary fibrosis pathogenesis.

 Senotherapeutics targeting senescent cells or senescence-associated secretory phenotypes show promise in idiopathic pulmonary fibrosis models.

Restoring autophagic flux reduces fibrotic responses in preclinical idiopathic pulmonary fibrosis models.

Targeting the senescence–autophagy crosstalk defines a mechanistically guided path beyond current antifibrotics.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(26)00040-4

https://sciencemission.com/senescence%E2%80%93autophagy-axis