How inosine influences astrocyte metabolism and reactivity

Mechanisms underlying astrocyte reactive states are not well understood as different stimuli have divergent effect on astrocytes.

The researchers identified inosine as a key fuel for reactive astrocytes and showed that equilibrative nucleoside transporter 2 (Ent2) controls inosine efflux to maintain astrocytic energy balance.

Loss of Ent2 elevates astrocyte reactivity in vitro and in vivo, linking purine metabolism to inflammatory astrocyte states.

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01191-X

https://sciencemission.com/Ent2-modulates-inosine-catabolism