Targeting interleukin-6 trans-signalling in neurodegeneration
IL-6 can support repair or promote inflammation in the CNS, depending on how and when receptor signalling is engaged.
Classical IL-6 signalling is relatively restricted, whereas trans-signalling expands IL-6 responsiveness to gp130-expressing cells.
Evidence from neurodegenerative and neuroinflammatory disorders suggests that trans-signalling capacity may be more informative than IL-6 levels alone.
IL-6 trans-signalling can amplify glial, neuronal, vascular, and immune-cell interactions that contribute to chronic neuroinflammation.
Selective inhibition of IL-6 trans-signalling may offer a way to limit inflammatory pathology while preserving beneficial classical IL-6 functions.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(26)00140-2
