Multiple roles of lysosomes in a cell
Damaged proteins and cellular components are degraded in lysosomes and the end products like amino acids, lipids, and iron, are exported by dedicated transporters for utilization in the cytoplasm.
The nutrients produced are transported across the lysosomal membrane via specialized signaling complexes that mediate communication with other organelles and control cell-wide programs for growth, catabolism, and stress response.
In immune cells, lysosomes play an important role in innate immune signaling, and inflammatory cell death, and in neurons, they are involved in organelle quality control, and neuroimmune crosstalk.
Un this review the authors discuss different pathways and players that position lysosomes as integrators of nutrient status and organelle health to drive tissue-specific physiology.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00031-6
